Adithya S. Sahasranamam

Adithya Subramanian Sahasranamam

adi.sahasranamam@gmail.com | New York, NY | LinkedIn

Research Experience

Research Technician - Generative AI for Drug Discovery

Memorial Sloan Kettering Cancer Center | New York, New York | July 2022 - Present

Leading generative AI and machine learning initiatives for novel cancer therapeutic development under Dr. Daniel S. Higginson.

  • Generative AI Drug Design: Design novel therapeutics using deep learning, reinforcement learning, and generative models (GANs, VAEs) for DNA repair proteins (ATM, Ligase IV, DNA-PKc, Rad51, Ku70/80)
  • Develop PROTAC, ADC, and AOC conjugates targeting NHEJ and Alt-EJ repair pathways using structure-based AI approaches
  • Deploy transformer-based models for molecular property prediction and binding affinity optimization
  • Build and manage bioinformatics pipelines (Illumina/Nanopore) with unsupervised learning for DNA repair pattern analysis
  • Collaborate on wet-lab validation of AI-generated therapeutic candidates

Research Scientist I

149 Bio, LLC | Miami, Florida | October 2021 - June 2022

Computational and Molecular Biologist developing novel integrin agonists to prevent WBC extravasation into periphery.

  • Developed and executed cell-based assays (ELISA, adhesion, migration) to evaluate therapeutics for IBD, Lupus, kidney disease, and cancer
  • Built integrin homology models and performed molecular docking for protein-ligand interaction prediction and drug optimization

Graduate Student Researcher

New Jersey Institute of Technology | Newark, New Jersey | January 2019 - May 2021

Thesis: The impact of IRAK-1 splice variants on inflammatory response in sepsis under Dr. Nan Gao, Dr. Patrick Morcillo & Dr. Dirk Bucher

  • Analyzed large-scale genetic data to investigate the role of IRAK-1 in sepsis-induced inflammatory response using Python-based bioinformatics pipelines
  • Demonstrated that pre-infection IRAK-1 levels dictate inflammatory response magnitude following endotoxin exposure

Education

Master of Science, Biology | New Jersey Institute of Technology | January 2019 - May 2021 Thesis: The Role of IRAK-1 in Sepsis

Bachelor of Science, Biology & Computer Science | Valparaiso University | August 2014 - May 2018 Minor: Chemistry

Certifications

Introduction to Molecular Modeling in Drug Discovery Schrödinger, 2022

Advanced Image Analysis using MATLAB Memorial Sloan Kettering Cancer Center, 2022

Skills

Programming & Development:

  • Python, R, MATLAB
  • Java
  • HTML, CSS, JavaScript, TypeScript
  • CI/CD, Version Control (Git)
  • Bash, Shell Scripting
  • Linux/Unix, HPC (SLURM, PBS, SGE)
  • Cloud Computing (AWS, GCP)
  • Database Design & Management (MySQL, PostgreSQL, MongoDB)
  • Parallel Computing, GPU Programming (CUDA)
  • Containerization (Docker, Singularity & Kubernetes)

AI/ML & Deep Learning:

  • TensorFlow, PyTorch
  • Generative AI & LLM development
  • Neural Networks, CNNs, RNNs, GANs,Diffusion Models & Transformers
  • Model Optimization & Hyperparameter Tuning
  • Transfer Learning, Few-Shot Learning

Structural Biology & Drug Discovery:

  • Protein Structure Prediction
  • Protein-Protein & Protein-Ligand Docking
  • Molecular Dynamics, Free-Energy Perturbations & GBSA
  • High-Throughput Virtual Screening
  • De Novo Structure-Based Drug/ADC/PROTAC/AOC Design
  • QSAR/QSPR Modeling
  • Binding Affinity Prediction
  • Pharmacophore Modeling

Bioinformatics:

  • Pipeline Development (Snakemake, Nextflow)
  • NGS Analysis (Illumina, Nanopore)
  • RNA-seq, ChIP-seq, ATAC-seq
  • Variant Calling (GATK, FreeBayes)
  • Genome Assembly, Annotation
  • Genomic, Transcriptopmic & proteomic analsyis
  • Sequence Alignment (BLAST, HMMER, Clustal)
  • Phylogenetic Analysis
  • Single-Cell Sequencing Analysis

Data Analysis & Visualization:

  • Statistical Analysis & Modeling
  • Data Mining & Pattern Recognition

Wet-Lab Techniques:

  • ELISA, Cell/Tissue Culture, Immunoassays
  • Cell Adhesion & Migration Assays
  • Electrophysiology, Patch Clamp
  • PCR/qPCR, RPA
  • Western Blotting, IFC & IHC
  • Protein, DNA Purification